Use of DNA Microarrays for Rapid Genotyping of TEM Beta-Lactamases That Confer Resistance
نویسندگان
چکیده
منابع مشابه
The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli.
Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. Especially, carbapenem antibiotics are hydrolyzed more efficiency than other beta-lactam antibiotics. The KPC enzymes are found most often in Enterobacte...
متن کاملThe structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34.
Widespread use of beta-lactam antibiotics has promoted the evolution of beta-lactamase mutant enzymes that can hydrolyze ever newer classes of these drugs. Among the most pernicious mutants are the inhibitor-resistant TEM beta-lactamases (IRTs), which elude mechanism-based inhibitors, such as clavulanate. Despite much research on these IRTs, little is known about the structural bases of their a...
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abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
15 صفحه اولPrevalence of TEM Beta-Lactamases and Determination of MIC of four Different Classes of Antibiotics in Klebsiella pneumonaia Clinical Isolates
Background & Aims: Organisms producing TEM-β-lactamase are emerging around the world as a source of resistance to β-lactam antibiotics such as three generation cephalosporins. In this study, we used a polymerase chain reaction (PCR) to identify genes TEM for Extended-spectrum β-lactamase (ESBLs) producing clinical isolates of Klebsiella pneumonia from hospitals of Boro...
متن کاملIntegrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes.
Extended-spectrum beta-lactamases (ESBL) of the TEM, SHV, or CTX-M type confer resistance to beta-lactam antibiotics in gram-negative bacteria. The activity of these enzymes against beta-lactam antibiotics and their resistance against inhibitors can be influenced by genetic variation at the single-nucleotide level. Here, we describe the development and validation of an oligonucleotide microarra...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2004
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.42.10.4918.2004